Formation of S-adenosylhomocysteine in the heart. II: A sensitive index for regional myocardial underperfusion.
نویسندگان
چکیده
منابع مشابه
Sensitive Index For Regional Myocardial Underperfusion
Rate of accumulation of myocardial S-adenosylhomocysteine (SAH) was used in an open-chest dog preparation as an index of free cytosolic adenosine levels. Following 30 minutes of coronary artery ligation and infusion of L-homocysteine thiolactone (10 /umol/kg/min i.v.) SAH levels increased from 1.3 (control) to 3.3 nmoles/g in the nonischemic and to values over 100 nmoles/g in the ischemic regio...
متن کاملFormation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine.
To assess the concentration of free intracellular adenosine in the heart the kinetic properties of cytosolic S-adenosylhomocysteine (SAH) hydrolase were utilized at elevated levels of L-homocysteine (adenosine + L-homocysteine in equilibrium with SAH + H2O). Global hypoxia was induced in the isolated perfused guinea pig heart by graded reduction of perfusion medium PO2 in the presence of satura...
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15 صفحه اولMyocardial Underperfusion
Rate of accumulation of myocardial S-adenosylhomocysteine (SAH) was used in an open-chest dog preparation as an index of free cytosolic adenosine levels. Following 30 minutes of coronary artery ligation and infusion of L-homocysteine thiolactone (10 /umol/kg/min i.v.) SAH levels increased from 1.3 (control) to 3.3 nmoles/g in the nonischemic and to values over 100 nmoles/g in the ischemic regio...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1988
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.63.1.250